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Topical emollient prevents the development of atopic dermatitis and atopic march in mice.
Zhang J, Xu X, Wang X, Zhang L, Hu M, Le Y, Chen L, Zheng J. Zhang J, et al. Exp Dermatol. 2023 Jul;32(7):1007-1015. doi: 10.1111/exd.14806. Epub 2023 Apr 8. Exp Dermatol. 2023. PMID: 37029953
Moreover, emollient treatments significantly downregulated expression levels of AD-related genes (286 of 1450 differentially expressed genes), including those related to innate inflammation (S100a8/a9, Il1b, Defb3/6, Mmp12), chemokines (Cxcl1/3, Ccl3/4) and epidermal perme …
Moreover, emollient treatments significantly downregulated expression levels of AD-related genes (286 of 1450 differentially expressed genes …
Skin and scale regeneration after mechanical damage in a teleost.
Costa RA, Power DM. Costa RA, et al. Mol Immunol. 2018 Mar;95:73-82. doi: 10.1016/j.molimm.2018.01.016. Epub 2018 Feb 4. Mol Immunol. 2018. PMID: 29407579
The integrity of the integument, as assessed by quantification of extracellular matrix (ECM) gene transcripts (fn1a, colIalpha1, colValpha2, colXalpha1, ogn1, ogn2, crtac1a, cyr61, pcna, krt2 and mmp9) was restored within 2 days. Epithelial-mesenchyme interactions assessed …
The integrity of the integument, as assessed by quantification of extracellular matrix (ECM) gene transcripts (fn1a, colIalpha1, colValpha2, …
Novel Quinazoline Derivative Induces Differentiation of Keratinocytes and Enhances Skin Barrier Functions against Th2 Cytokine-Mediated Signaling.
Park Y, Srigouri H, Kim D. Park Y, et al. Molecules. 2023 Aug 18;28(16):6119. doi: 10.3390/molecules28166119. Molecules. 2023. PMID: 37630370 Free PMC article.
Our results demonstrated that SH-340 significantly increased factors for differentiation and skin barrier function including KRT1, KRT2, KRT10, IVL, LOR, CLDN1, OVOL1, and FLG, whereas it inhibited TSLP expression in a dose-dependent manner, both at the mRNA and protein le …
Our results demonstrated that SH-340 significantly increased factors for differentiation and skin barrier function including KRT1, KRT2
Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis.
Pavez Loriè E, Cools M, Borgers M, Wouters L, Shroot B, Hagforsen E, Törmä H, Vahlquist A. Pavez Loriè E, et al. Br J Dermatol. 2009 Jan;160(1):26-36. doi: 10.1111/j.1365-2133.2008.08895.x. Epub 2008 Oct 21. Br J Dermatol. 2009. PMID: 19016711 Clinical Trial.
RESULTS: Talarozole treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose dependently, and decreased the expression of KRT2 and IL-1alpha compared with vehicle-treated skin. No mRNA change in retinol-metabolizing enzymes was obtained. There was …
RESULTS: Talarozole treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose dependently, and decreased the express …
RNA-sequencing of paired tape-strips and skin biopsies in atopic dermatitis reveals key differences.
Fritz B, Halling AS, Cort ID, Christensen MO, Rønnstad ATM, Olesen CM, Knudgaard MH, Zachariae C, Heegaard S, Thyssen JP, Bjarnsholt T. Fritz B, et al. Allergy. 2024 Mar 13. doi: 10.1111/all.16086. Online ahead of print. Allergy. 2024. PMID: 38477552
Tape-strips preferentially detected many itch (CCL3/CCL4/OSM) and immune-response (CXCL8/IL4/IL5/IL22) genes as well as markers of epidermal dendritic cells (CD1a/CD207), while certain cytokines (IL18/IL37), skin-barrier genes (KRT2/FLG2), and dermal fibroblasts markers (C …
Tape-strips preferentially detected many itch (CCL3/CCL4/OSM) and immune-response (CXCL8/IL4/IL5/IL22) genes as well as markers of epidermal …
Skin wound healing in gilthead seabream (Sparus aurata L.) fed diets supplemented with arginine.
Chen Z, Ceballos-Francisco D, Guardiola FA, Huang D, Esteban MÁ. Chen Z, et al. Fish Shellfish Immunol. 2020 Sep;104:347-358. doi: 10.1016/j.fsi.2020.06.026. Epub 2020 Jun 13. Fish Shellfish Immunol. 2020. PMID: 32544556
Compared with the CON diet, the ARG1 diet remarkedly depressed the gene expression of mpo, il-8, and tnf-alpha, and enhanced the gene expression of tgf-beta1, igf-1, pcna, krt2, mmp9, fn1alpha, and colIalpha and the antioxidant enzyme cat in the skin tissues after wounding …
Compared with the CON diet, the ARG1 diet remarkedly depressed the gene expression of mpo, il-8, and tnf-alpha, and enhanced the gene expres …
Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole.
Pavez Loriè E, Gånemo A, Borgers M, Wouters L, Blockhuys S, van de Plassche L, Törmä H, Vahlquist A. Pavez Loriè E, et al. Acta Derm Venereol. 2009;89(1):12-20. doi: 10.2340/00015555-0573. Acta Derm Venereol. 2009. PMID: 19197536 Free article. Clinical Trial.
We first compared the mRNA expression of cellular retinoic acid binding protein II (CRABPII), keratin (KRT) 2 and 4, CYP26A1 and B1, and two markers of inflammation (interleukin-1alpha and tumours necrosis factor (TNF)-alpha) in shave biopsies from 11 genetically defined, …
We first compared the mRNA expression of cellular retinoic acid binding protein II (CRABPII), keratin (KRT) 2 and 4, CYP26A1 and B1, and two …